Dr Sean Brady’s team at New York’s Rockefeller University has been busy unearthing antibiotics using a gene sequencing technique to analyse more than 1,000 soil samples taken from across the US and and they discovered malacidins. Their discovery represents the first discovery of a new class of antibiotic since the discovery of teixobactin in 2015…
The ROBOX Project
Oxygen functionalities are key functional groups in many of today’s chemicals and materials. The efficient introductions of oxygen-functionalities into raw materials are key chemical transformations in bulk and fine chemicals. Innovative bio-catalytic oxidation routes using molecular oxygen (from air) under benign and mild (pH) conditions such as ambient temperature and pressure can greatly improve the sustainability and economics of processes, but are so far mainly been applied in the pharma segments. In this segment, the enzyme-catalyzed step often represents the highest added value and the high price of the end-product (> €1000/kg) justifies less than optimal enzyme production and limitations in its catalytic efficiency. In order to achieve the widening of industrial application of enzymatic bio-oxidation processes to also larger volume but lower price chemical markets, ROBOX will demonstrate the techno-economic viability of bio-transformations of four types of robust oxidative enzymes: P450 monooxygenases (P450s), Baeyer-Villiger MonoOxygenase (BVMOs), Alcohol DeHydrogenase (ADH) and Alcohol OXidase (AOX) for which target reactions have already been validated on lab-scale in pharma, nutrition, fine & specialty chemicals and materials applications.
The introduction of ROBOX bio-oxidation processes is expected to bring substantial reductions in cost (up to -50%), energy use (-60%), chemicals (-16%) and GHG-emissions (-50%).
The ROBOX project has an integrated work-flow structure of 7 work packages.
The intensive networking with our scientific partners enables us to keep at the front line of top-level research and strengthens the knowledge base in the field of industrial biotechnology.
Our ROBOX partners at UM and RUG have been using BVMO enzymes to synthesize lactones for polymer applications Exploring the Substrate Scope of Baeyer-Villiger Monooxygenases with Branched Lactones as Entry towards Polyesters Full Paper Our partner UAB have published a ROBOX publication on immobilized self-sufficient Baeyer–Villiger monooxygenases is discussed. An immobilized and highly stabilized self-sufficient…
The 7th EuCheMS Chemistry conference, 26-30 August 2018 is in Liverpool, UK. The conference has excellent keynote speakers, and there is still time for submitting abstracts for oral and poster presentations (deadline February 19). See https://www.euchems2018.org/ Although the conference covers all aspects of catalysis there is a strong biocatalysis lineup. Biological catalysis Convenor: Dick Janssen…