ROBOX: Expanding the industrial use of Robust Oxidative Biocatalysts for the conversion and production of alcohols

The ROBOX Project

Oxygen functionalities are key functional groups in many of today’s chemicals and materials. The efficient introductions of oxygen-functionalities into raw materials are key chemical transformations in bulk and fine chemicals. Innovative bio-catalytic oxidation routes using molecular oxygen (from air) under benign and mild (pH) conditions such as ambient temperature and pressure can greatly improve the sustainability and economics of processes, but are so far mainly been applied in the pharma segments. In this segment, the enzyme-catalyzed step often represents the highest added value and the high price of the end-product (> €1000/kg) justifies less than optimal enzyme production and limitations in its catalytic efficiency. In order to achieve the widening of industrial application of enzymatic bio-oxidation processes to also larger volume but lower price chemical markets, ROBOX will demonstrate the techno-economic viability of bio-transformations of four types of robust oxidative enzymes: P450 monooxygenases (P450s), Baeyer-Villiger MonoOxygenase (BVMOs), Alcohol DeHydrogenase (ADH) and Alcohol OXidase (AOX) for which target reactions have already been validated on lab-scale in pharma, nutrition, fine & specialty chemicals and materials applications.

The introduction of ROBOX bio-oxidation processes is expected to bring substantial reductions in cost (up to -50%), energy use (-60%), chemicals (-16%) and GHG-emissions (-50%).

Work Packages

The ROBOX project has an integrated work-flow structure of 7 work packages.


The intensive networking with our scientific partners enables us to keep at the front line of top-level research and strengthens the knowledge base in the field of industrial biotechnology.

ROBOX Publications

Read articles from our news archive, newsletters and brochures, ROBOX publications, and deliverable reports.

Our Partners

Latest news

Applied Biobased Materials Conference (ABC) 2018

ROBOX to have a presence at Applied Biobased Materials Conference (ABC) 2018 hosted by the Aachen-Maastricht Institute for Biobased Materials (AMIBM). This will describe some of our latest developments in using biocatalysis to synthesize materials suitable for innovations. https://www.maastrichtuniversity.nl/events/applied-biobased-materials-conference-abc-2018

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1 8 TH- 2 0 TH OF A P R I L 2 0 1 8 PROCESS DEVELOPMENT FOR BIOOXIDATIONS WORKSHOP Biooxidations Workshop The objective of this workshop is to elaborate on biocatalytic process development. In many cases it is useful to assess biocatalytic reactions at a very early stage of development, before a process…

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