Here are our latest posters that give more details about our results. Please contact us if you wish to find out more. From ACIB some results on drug metabolite synthesis – Combinatorial Optimization strategies to increase Human P450 catalytic Activity in whole cell Biotransformations From DTU two posters on implementation of biooxidation – Kinetic Evaluation…Details
Our latest publication describes further developments at our partner RUG in fusion enzymes for co-factor recycling.
See “What to sacrifice? Fusions of cofactor regenerating enzymes with Baeyer-Villiger monooxygenases and alcohol dehydrogenases for self-sufficient redox biocatalysis”
Read more about our portfolio of cytochrome P450 enzymes in Exploring the Biocatalytic Potential of a Self‐Sufficient Cytochrome P450 from Thermothelomyces thermophila
Read our latest review article on monooxygenases
Beyond active site residues: overall structural dynamics control catalysis in flavin-containing and heme-containing monooxygenases
Read our publication “A hydroquinone-specific screening system for directed P450 evolution” This was published by our partner RWTH Aachen and describes the direct hydroxylation of benzene to hydroquinone (HQ) under mild reaction conditions that is a challenging task for chemical catalysts.
High performing immobilized Baeyer-Villiger monooxygenase and glucose dehydrogenase for the synthesis of ε-caprolactone derivative
This paper describes co-immobilized biocatalyst enzymes that allows cofactor regeneration and higher yields.
See our latest paper that demonstrates the environmental metrics of our biocatalysis technology
A prospective life‐cycle assessment (LCA) of monomer synthesis: Comparison of biocatalytic and oxidative chemistry
See our VIP award winning publication on fused oxidation enzymes
“Design of Artificial Alcohol Oxidases: Alcohol Dehydrogenase–NADPH Oxidase Fusions for Continuous Oxidations”
Our latest publication from RUG/UP has applied cumulative alanine mutagenesis approach to cyclohexanone monooxygenase from Thermocrispum municipale, a flavin-dependent Baeyer-Villiger monooxygenase to demonstrate “Side-Chain Pruning Has Limited Impact on Substrate Preference in a Promiscuous Enzyme”
Our partner RUG have published a paper on how ROBOX catalysts can be used to add value to glycerol – a byproduct of biodiesel production that is treated as waste.
“Structure-based engineering of Phanerochaete chrysosporium alcohol oxidase for enhanced oxidative power towards glycerol”
See ROBOX latest publication from RUGDetails
RUG made a significant contribution to this paper on enzyme improvement Manipulating the stereoselectivity of the thermostable Baeyer–Villiger monooxygenase TmCHMO by directed evolution Abstract UAB have led the publication of a collaborative ROBOX paper An immobilized and highly stabilized self-sufficient monooxygenase as biocatalyst for oxidative biotransformations Full Paper UNIMAN publish a new paper on…Details
Toni Glieder HemeEnzymes_Certosa Toni Glieder Expression Certosa Marco Fraaije Redox biocatalysts ROBOX Marco Fraaije Redox biocatalysts ROBOX2 Nick Turner ROBOX Carbazymes Summer School Oct 2017 Martin Schuerman Summer-School_Siena2017_Biocat-Processes Martin Schuerman Summer-School_Siena2017_Hydroxylated-Products
Baeyer-Villiger monooxygenases (BVMOs) as entry to lactones and their polyesters from UM with RUG SUBSTRATE SPECIFICITY OF CYP505X FROM ASPERGILLUS FUMIGATUS from TUG Evolution of cytochrome P450 BM3 towards aromatic hydroxylation from RWTH Evolution of P450 BM3 towards improved performance of allylic oxidation from RWTH Alcohol to Lactone cascade with ADH – CHMO fusions from RUG…Details
READ ROBOX PUBLICATIONS Please Note: These are open access papers but some have a publication delay imposed by the publisher on them and this facility and will become available soon PARTNER TITLE LINK RUG Biocatalytic properties and structural analysis of eugenol oxidase from Rhodococcus jostii RHA1: a versatile oxidative biocatalyst http://europepmc.org/articles/PMC5089669 UNIMAN/UP One-pot Biocatalytic Double Oxidation…Details