Biotechnology finds new antibiotic

Dr Sean Brady’s team at New York’s Rockefeller University has been busy unearthing antibiotics using a gene sequencing technique to analyse more than 1,000 soil samples taken from across the US and and they discovered malacidins. Their discovery represents the first discovery of a new class of antibiotic since the discovery of teixobactin in 2015…

LATEST PUBLICATIONS

Read more about our portfolio of cytochrome P450 enzymes in Exploring the Biocatalytic Potential of a Self‐Sufficient Cytochrome P450 from Thermothelomyces thermophila

Read our latest review article on monooxygenases
Beyond active site residues: overall structural dynamics control catalysis in flavin-containing and heme-containing monooxygenases

Read our publication “A hydroquinone-specific screening system for directed P450 evolution” This was published by our partner RWTH Aachen and describes the direct hydroxylation of benzene to hydroquinone (HQ) under mild reaction conditions that is a challenging task for chemical catalysts.

High performing immobilized Baeyer-Villiger monooxygenase and glucose dehydrogenase for the synthesis of ε-caprolactone derivative

This paper describes co-immobilized biocatalyst enzymes that allows cofactor regeneration and higher yields.

See our latest paper that demonstrates the environmental metrics of our biocatalysis technology
A prospective life‐cycle assessment (LCA) of monomer synthesis: Comparison of biocatalytic and oxidative chemistry

See our VIP award winning publication on fused oxidation enzymes
“Design of Artificial Alcohol Oxidases: Alcohol Dehydrogenase–NADPH Oxidase Fusions for Continuous Oxidations”

Our latest publication from RUG/UP has applied cumulative alanine mutagenesis approach to cyclohexanone monooxygenase from Thermocrispum municipale, a flavin-dependent Baeyer-Villiger monooxygenase to demonstrate “Side-Chain Pruning Has Limited Impact on Substrate Preference in a Promiscuous Enzyme”

Our partner RUG have published a paper on how ROBOX catalysts can be used to add value to glycerol – a byproduct of biodiesel production that is treated as waste.
“Structure-based engineering of Phanerochaete chrysosporium alcohol oxidase for enhanced oxidative power towards glycerol”

See ROBOX latest publication from RUG

7th EuCheMS Chemistry Congress

The 7th EuCheMS Chemistry conference, 26-30 August 2018 is in Liverpool, UK. The conference has excellent keynote speakers, and there is still time for submitting abstracts for oral and poster presentations (deadline February 19). See https://www.euchems2018.org/ Although the conference covers all aspects of catalysis there is a strong biocatalysis lineup. Biological catalysis Convenor: Dick Janssen…

ROBOX Partners part of BIOCASCADES ITN meeting

The 1st BIOCASCADES Symposium “Reaction Concepts for Industrial Biocatalysis” will take place on April 9th – 11th 2018 in Bielefeld, Germany. The conference will bring together 100 participants from academia and industry offering network opportunities and fostering discussions on current advances in industrial biocatalysis. The lectures will be divided into three scientific sessions: Process Catalysis…