KETOREDUCTASES – patent from cLEcta partner of ROBOX

Our partner cLEcta have had their patent “KETOREDUCTASES” WO 2019/012095 A1 published. This invention relates to ketoreductases and their use that are particularly useful for enzymatically catalyzing the reduction of ketones to chiral or non-chiral secondary alcohols and oxidation of chiral or non-chiral secondary alcohols to ketones. Andreas Vogel (one of the inventors) from cLEcta…

Read about our metrics that demonstrate improved environmental performance

In our publication “A Prospective Life Cycle Assessment (LCA) of Monomer Synthesis: Comparison of Biocatalytic and Oxidative Chemistry” out partners University of Maastrict and DTU have analysed our biochemical synthesis of lactones obtained by Baeyer–Villiger oxidation and compared this to more traditional chemical methods. This allowed us to quantify the environmental impact of our products…

ENZYMES FOR PIGMENT SURFACE OXIDATION

Geert Deroover from Chemstream delivers his presentation In this novel development our partner Chemstream have developed a range of techniques to produce improved formulations for inks based on biooxidative enzyme modifications of pigments and polymers. This presentation given at our recent workshop at Dechema describes some of the developments in “ROBOX pigment oxidation by ChemStream”…

Find out about some of our results from these posters

1. What can oxidative biocatalysis do for polymeric materials? Our partners from Maastricht describe the use of Bayer-Villiger monooxygenases to synthesize substitituted caprolactones which are used to make novel polymers. 2. Selective alcohol oxidations with artificial oxidases: alcohol dehydrogenase – NADPH oxidase fusions RUG Groningen describe resolution of alcohols by enantiomeric oxidation with these fusion…

A hydroquinone-specific screening system for directed P450 evolution

Read our publication on this topic. It describes the direct hydroxylation of benzene to hydroquinone (HQ) under mild reaction conditions is a challenging task for chemical catalysts. A screening protocol designed for screening of P450 variants capable of producing hydroquinones. The hydroquinone quantification assay is based on the interaction of 4-nitrophenylacetonitrile (NpCN) with hydroquinones under…

ROBOX Engages more young scientists at ACIB

Our partner TU Graz hosted a school visit – Basics of Biotechnology for 13-14 year old school scientists. In three exercises, they experienced different laboratory techniques: streaking and growing microorganisms like bakers yeast, isolating DNA from fruits and vegetables and simulating a protein engineering exercise by doing a colorimetric assay on active and inactive clones.…