As part of our activities at CPhI our partner TUG promoted the stable lyophilised CYP450 products developed as part of ROBOX. Now on offer to industry is robust CYPs for screening and upscaling from the Austrian Centre of Industrial Biotechnology (ACIB) from within the ROBOX are lyophilised CYP biocatalysts that retain full activity – even…
On Saturday 6th of October ROBOX presented at the Day of Chemistry at Chemelot in Geleen (NL) and Maastricht University presented to an open general audience. In total there were 2500 visitors and the ROBOX attracted interest in the area of biotechnology. poster Dr Katrien Bernaerts presents ROBOX to a wider audience. Chemelot stands for…
Recently ROBOX oxidation technology was recently widely publicized at the leading pharmaceutical industrial showcase exhibition CPhI in Madrid. Led by our partner TUG this was an excellent opportunity to promote our use of CYP450 technology to produce pharmaceutically relevant metabolites. CLE also promoted their combination of ADH and NOX technology for alcohol oxidation. IF YOU…
The European Commission has reviewed the progress of the Bioeconomy Strategy and Action Plan and published a comprehensive update. A short video explains the value of the plan and the integrated approach to the European bioeconomy – A new bioeconomy for a sustainable Europe A detailed document reviews the actions so far and gives outlines…
Using the power of directed evolution of enzymes to solve practical problems is at the core of ROBOX activities. This science has been recognised by the Nobel Committee in their decision to award this years prize for chemistry to three researchers who have contributed greatly to opening these new avenues to chemical discovery for vital…
Our partner RUG have published a detailed protocol to generate mutant libraries experimentally by primer design, mutagenesis, protein production and screening and then mutation combination strategies that can yield stabilized mutants with increases in apparent melting temperature of 20–35°C and vastly increased half-lives with resistance to cosolvents. These mutants were designed using algorithms to predict…
The ROBOX project is planning a final meeting and workshop on Feb 13th and 14th 2019 to promote all the results and look for ways other stakeholders can get involved with use and exploitation. The major results from all our demonstation projects will be released. Please get in touch if you are interested in biooxidations.…
There was a major ROBOX presence presence at Biocat18 in Hamburg with several of our major results presented in lectures and posters with RUG TUG and UNIMAN all participating. Our coordinator Marco recieved the major BIOCAT science award for 2018 A ROBOX presentation Partner UNIMAN presented a poster on a new family of drug metabolite…
As part of our ROBOX biooxidation workshop that was implemented in June (see here) we have now issued a video that gives an overview on this workshop. See video here DTU plan future versions of this workshop both as open versions or private for single companies so if you want to take part please contact…
Our partner DTU that is leading the work package on engineering the scale-up of biooxidations presented ROBOX reults at the leading international Gordon Research Seminar. These types of stability and oxygen supply studies are vital to enable biooxidation to be performed at an industrial scale.