160 INNO KIP by P450 & ADH_InnoSyn_20180304
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159 INNO Cyclopentadecanone-BVMO_InnoSyn_20180304
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MORE DETAILS OF ROBOX PROJECT WORKSHOP
1 8 TH- 2 0 TH OF A P R I L 2 0 1 8 PROCESS DEVELOPMENT FOR BIOOXIDATIONS WORKSHOP Biooxidations Workshop The objective of this workshop is to elaborate on biocatalytic process development. In many cases it is useful to assess biocatalytic reactions at a very early stage of development, before a process…
158 UM Abstract_ABC_conference Marie
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Biotechnology finds new antibiotic
Dr Sean Brady’s team at New York’s Rockefeller University has been busy unearthing antibiotics using a gene sequencing technique to analyse more than 1,000 soil samples taken from across the US and and they discovered malacidins. Their discovery represents the first discovery of a new class of antibiotic since the discovery of teixobactin in 2015…
LATEST PUBLICATIONS
Our latest publication describes further developments at our partner RUG in fusion enzymes for co-factor recycling.
See “What to sacrifice? Fusions of cofactor regenerating enzymes with Baeyer-Villiger monooxygenases and alcohol dehydrogenases for self-sufficient redox biocatalysis”
Read more about our portfolio of cytochrome P450 enzymes in Exploring the Biocatalytic Potential of a Self‐Sufficient Cytochrome P450 from Thermothelomyces thermophila
Read our latest review article on monooxygenases
Beyond active site residues: overall structural dynamics control catalysis in flavin-containing and heme-containing monooxygenases
Read our publication “A hydroquinone-specific screening system for directed P450 evolution” This was published by our partner RWTH Aachen and describes the direct hydroxylation of benzene to hydroquinone (HQ) under mild reaction conditions that is a challenging task for chemical catalysts.
High performing immobilized Baeyer-Villiger monooxygenase and glucose dehydrogenase for the synthesis of ε-caprolactone derivative
This paper describes co-immobilized biocatalyst enzymes that allows cofactor regeneration and higher yields.
See our latest paper that demonstrates the environmental metrics of our biocatalysis technology
A prospective life‐cycle assessment (LCA) of monomer synthesis: Comparison of biocatalytic and oxidative chemistry
See our VIP award winning publication on fused oxidation enzymes
“Design of Artificial Alcohol Oxidases: Alcohol Dehydrogenase–NADPH Oxidase Fusions for Continuous Oxidations”
Our latest publication from RUG/UP has applied cumulative alanine mutagenesis approach to cyclohexanone monooxygenase from Thermocrispum municipale, a flavin-dependent Baeyer-Villiger monooxygenase to demonstrate “Side-Chain Pruning Has Limited Impact on Substrate Preference in a Promiscuous Enzyme”
Our partner RUG have published a paper on how ROBOX catalysts can be used to add value to glycerol – a byproduct of biodiesel production that is treated as waste.
“Structure-based engineering of Phanerochaete chrysosporium alcohol oxidase for enhanced oxidative power towards glycerol”
See ROBOX latest publication from RUG
7th EuCheMS Chemistry Congress
The 7th EuCheMS Chemistry conference, 26-30 August 2018 is in Liverpool, UK. The conference has excellent keynote speakers, and there is still time for submitting abstracts for oral and poster presentations (deadline February 19). See https://www.euchems2018.org/ Although the conference covers all aspects of catalysis there is a strong biocatalysis lineup. Biological catalysis Convenor: Dick Janssen…
Winter Process Chemistry Conference in Manchester
The ‘5th Winter Process Chemistry Conference’ will be held in Manchester at the MCC, December 11th – 13th 2018. Our partner UNIMAN will present on biocatalysis for use in industry.
There is a student rate to attend and also an opportunity for them to present a poster.
ROBOX Partners part of BIOCASCADES ITN meeting
The 1st BIOCASCADES Symposium “Reaction Concepts for Industrial Biocatalysis” will take place on April 9th – 11th 2018 in Bielefeld, Germany. The conference will bring together 100 participants from academia and industry offering network opportunities and fostering discussions on current advances in industrial biocatalysis. The lectures will be divided into three scientific sessions: Process Catalysis…
More Details on Cytochrome P450 Metabolite Synthesis
Our partner InnoSyn have published further details on this valuable technology PRODUCTION OF DICLOFENAC METABOLITES BY APPLYING CYTOCHROME P450 TECHNOLOGY http://www.teknoscienze.com/tks_article/production-of-diclofenac-metabolites-by-applying-cytochrome-p450-technology/ Cytochrome P450 monooxygenases can catalyze highly regio- and stereo-selective oxidations of many organic compounds. Nevertheless, the scale-up of such biooxidations remains challenging due to the often-low activity, level of expression and stability of P450…