A paper “Unraveling the Molecular Determinants of Bee Sensitivity to Neonicotinoid Insecticides” describing collaborative work between Exeter University, Rothampstead and Bayer have shown that insecticides with very low impacts on bees is possible. This is due to cytochrome P450s of the CYP9Q subfamily determine bee sensitivity to neonicotinoids. Cytochrome P450s are one of the target family of enzymes for ROBOX.