The thermophilic fungus Thermothelomyces thermophila is currently being investigated by a team of Dutch and Italian researchers in the frame of the ROBOX project that is particularly devoted on the development of possibly robust methods for the oxidation of industrially relevant compounds. One of the notoriously difficult reactions to be performed in chemical synthesis is the selective oxidation of compounds that is fuelled by air. Enzymes very often outperform chemical strategies in certain aspects. The so-called Baeyer-Villiger oxidation is a typical example for a reaction where chemical processes are faced with severe environmental and safety concerns: Enzymes are a pretty good alternative to selectively insert an oxygen into a C-C bond.