Good review of this essentiial feature of Cytochrome P450s for application


  • Thermostability is a desirable feature for using P450s in industrial processes
  • The structures of four P450s from thermophiles have been characterized to date.
  • P450s from thermophiles tend to be shorter overall than those from mesophiles.
  • Extended salt-bridged and aromatic networks may stabilize the P450 fold.
  • Directed evolution has been used to increase the thermostability of mesophilic P450s.